Square hall shrine datable to the 11th-13th centuries, at the time of the Italo-Greek monks venerating the Divine Wisdom. From 1504 it was the headquarter of the Mount of Mercy founded by the Papasiderese Franceschino Forestiero with the purpose of distributing free grain to the poor.

There, he commissioned the frescoes of the Pieta and Ss. Apollonia, Catherine, Lucy, Peter and Paul. Upon his death, the charitable work was continued by a family member of the same name, who, in 1569, decided to add the images of SS. Rocco and Blaise. In 1593 the bishop of Cassano validated the establishment, in a contiguous location to the chapel but with other purposes, of the new Mount of Mercy.

After the plague of 1656, the frescoes of the Virgin of Constantinople Enthroned and St. Sophia, are due to the patrician fellow citizen Florena Mastrota. With these works, the chapel's link with Mercurian monasticism was recomposed and the ideal continuity with the two Mounts of Mercy was highlighted.